Limited evidence to recommend lactate kinetics-guided therapy

Limited evidence to recommend lactate kinetics-guided therapy

We congratulate Zhou and colleagues on their randomized trial comparing central venous oxygen saturation (ScvO2)and lactate-driven resuscitation in septic shock [1] and would like to offer the following comments. Only the use of inotropes and blood transfusions were triggered by lactate kinetics or ScvO2 according to the reported treatment algorithms. There was no difference in those treatments...

Limited evidence to recommend against open chest cardiopulmonary resuscitation in blunt trauma

Main Text We congratulate Endo and co-authors on their retrospective registry-based analysis comparing closed-chest cardiopulmonary resuscitation (CCCPR) and open-chest cardiopulmonary resuscitation (OCCPR) in cardiac arrest patients following blunt trauma [1] and would like to share the following comments. OCCPR is generally deemed futile in blunt trauma patients whenever cardiopulmonary resus...

Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation.

A critical issue in brain energy metabolism is whether lactate produced within the brain by astrocytes is taken up and metabolized by neurons upon activation. Although there is ample evidence that neurons can efficiently use lactate as an energy substrate, at least in vitro, few experimental data exist to indicate that it is indeed the case in vivo. To address this question, we used a modeling ...

Is there sufficient evidence to recommend antiviral therapy in hepatitis C?

While patients with chronic hepatitis C virus (HCV) infection are treated in order to prevent liver-related morbidity and mortality, we rely on sustained virological response (SVR) as a virological biomarker to evaluate treatment efficacy in both clinical practice as well as in drug development. However, conclusive evidence for the clinical benefit of antiviral therapy or validity of SVR as sur...

Review: limited evidence to support pharmacological therapy for amphetamine withdrawal.